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1. (WO2017035357) PHOSPHONATE COMPOUNDS FOR TREATMENT OF MEDICAL DISORDERS

Pub. No.:    WO/2017/035357    International Application No.:    PCT/US2016/048704
Publication Date: Fri Mar 03 00:59:59 CET 2017 International Filing Date: Fri Aug 26 01:59:59 CEST 2016
IPC: C07F 9/40
C07D 403/12
A61K 31/401
Applicants: ACHILLION PHARMACEUTICALS, INC.
Inventors: WANG, Qiuping
GADHACHANDA, Venkat, Rao
WANG, Xiangzhu
DESHPANDE, Milind
PAIS, Godwin
CHEN, Dawei
WILES, Jason, Allan
HASHIMOTO, Akihiro
PHADKE, Avinash, S.
AGARWAL, Atul
Title: PHOSPHONATE COMPOUNDS FOR TREATMENT OF MEDICAL DISORDERS
Abstract:
Compounds, methods of use, and processes for making inhibitors of complement Factor D comprising Formula (I), or a pharmaceutically acceptable salt or composition thereof wherein R¹² or R¹³ on the A group is a phosphonate substituent (R³²) are provided. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade. The inhibitors of Factor D described herein reduces the excessive activation of complement.