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|1. (WO2017035357) PHOSPHONATE COMPOUNDS FOR TREATMENT OF MEDICAL DISORDERS|
|Applicants:||ACHILLION PHARMACEUTICALS, INC.
GADHACHANDA, Venkat, Rao
WILES, Jason, Allan
PHADKE, Avinash, S.
|Title:||PHOSPHONATE COMPOUNDS FOR TREATMENT OF MEDICAL DISORDERS|
Compounds, methods of use, and processes for making inhibitors of complement Factor D comprising Formula (I), or a pharmaceutically acceptable salt or composition thereof wherein R¹² or R¹³ on the A group is a phosphonate substituent (R³²) are provided. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade. The inhibitors of Factor D described herein reduces the excessive activation of complement.