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1. (WO2017035349) AMIDE COMPOUNDS FOR TREATMENT OF MEDICAL DISORDERS

Pub. No.:    WO/2017/035349    International Application No.:    PCT/US2016/048690
Publication Date: Fri Mar 03 00:59:59 CET 2017 International Filing Date: Fri Aug 26 01:59:59 CEST 2016
IPC: A61K 31/40
A61K 31/167
A61K 31/395
C07D 401/14
C07D 403/14
C07D 471/04
Applicants: ACHILLION PHARMACEUTICALS, INC.
Inventors: WILES, Jason, Allan
PHADKE, Avinash, S.
DESHPANDE, Milind
AGARWAL, Atul
CHEN, Dawei
GADHACHANDA, Venkat, Rao
HASHIMOTO, Akihiro
PAIS, Godwin
WANG, Qiuping
WANG, Xiangzhu
Title: AMIDE COMPOUNDS FOR TREATMENT OF MEDICAL DISORDERS
Abstract:
Compounds, methods of use, and processes for making inhibitors of complement Factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof wherein R12 or R13 on the A group is an amide substituent (R32) are provided. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade. The inhibitors of Factor D described herein are capable of reducing the excessive activation of complement.