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|1. (WO2017035349) AMIDE COMPOUNDS FOR TREATMENT OF MEDICAL DISORDERS|
|Applicants:||ACHILLION PHARMACEUTICALS, INC.
|Inventors:||WILES, Jason, Allan
PHADKE, Avinash, S.
GADHACHANDA, Venkat, Rao
|Title:||AMIDE COMPOUNDS FOR TREATMENT OF MEDICAL DISORDERS|
Compounds, methods of use, and processes for making inhibitors of complement Factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof wherein R12 or R13 on the A group is an amide substituent (R32) are provided. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade. The inhibitors of Factor D described herein are capable of reducing the excessive activation of complement.