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1. (WO2017035343) IMMUNOASSAY WITH ENHANCED SENSITIVITY

Pub. No.:    WO/2017/035343    International Application No.:    PCT/US2016/048672
Publication Date: Fri Mar 03 00:59:59 CET 2017 International Filing Date: Fri Aug 26 01:59:59 CEST 2016
IPC: G01N 33/53
G01N 33/532
G01N 33/533
G01N 33/543
Applicants: ACCESS MEDICAL SYSTEMS, LTD.
Inventors: ZUK, Robert F.
TAN, Hong
XIA, Qing
LI, Pu
CHEN, Haode
WU, Heng
Title: IMMUNOASSAY WITH ENHANCED SENSITIVITY
Abstract:
The present invention is directed to methods for increasing sensitivities of immunoassays. The invention utilizes an acid elution condition that preferentially elute specifically bound immune complexes over non-specifically bound complexes from a solid phase, and designs immunoassay protocols that improve the ratio of specific binding to non-specific binding and thereby improving assay sensitivity. The protocol determines the signal of the labeled immunocomplexes eluted from a solid phase.