Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2017035315) METHODS AND DEVICE FOR PHENOTYPIC CLASSIFICATION OF CELLS BASED ON MIGRATORY BEHAVIOR
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/035315 International Application No.: PCT/US2016/048575
Publication Date: 02.03.2017 International Filing Date: 25.08.2016
IPC:
A61P 35/00 (2006.01) ,C07K 16/28 (2006.01) ,C12M 3/00 (2006.01) ,G01N 33/50 (2006.01) ,G01N 33/574 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
M
APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3
Tissue, human, animal or plant cell, or virus culture apparatus
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
574
for cancer
Applicants:
THE JOHNS HOPKINS UNIVERSITY [US/US]; 3400 N. Charles Street Baltimore, MD 21218, US
Inventors:
KILIC, Onur; US
SCHIAPPARELLI, Paula, V.; US
QUINONES-HINOJOSA, Alfredo; US
LEVCHENKO, Andre; US
Agent:
HAILE, Lisa, A.; US
HIERHOLZER, Matthew, J.; US
LEAL, Peter, R.; US
BECHTEL, Pamela, E.; US
ALBERTI, David, L.; US
Priority Data:
62/210,86027.08.2015US
Title (EN) METHODS AND DEVICE FOR PHENOTYPIC CLASSIFICATION OF CELLS BASED ON MIGRATORY BEHAVIOR
(FR) PROCÉDÉS ET DISPOSITIF POUR LA CLASSIFICATION PHÉNOTYPIQUE DE CELLULES BASÉE SUR LE COMPORTEMENT MIGRATOIRE
Abstract:
(EN) The present invention provides a device and methods that allow time-resolved studies of migration with single-cell resolution on a fibrillary surface that mimics in vivo migration of cells. This platform is utilized for a high-content screen of patient-specific glioblastoma samples to analyze heterogeneities in the phenotype of migratory cells. The information the platform provides has prognostic value as it shows significant differences in time to recurrence and tumor location based on phenotypic classifiers.
(FR) La présente invention concerne un dispositif et des procédés qui permettent des études à résolution temporelle de migration avec une résolution monocellulaire sur une surface fibrillaire qui imite la migration in vivo de cellules. Cette plate-forme est utilisée pour le tri, avec un contenu élevé, d'échantillons de glioblastome spécifiques à un patient pour analyser les hétérogénéités dans le phénotype de cellules migratoires. Les informations que la plate-forme fournit ont une valeur de pronostic puisqu'elles présentent des différences significatives dans le temps en termes de récurrence et d'emplacement de tumeur sur la base des classificateurs phénotypiques.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)