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1. (WO2017035274) TRANSGENIC ANIMAL FOR PRODUCTION OF ANTIBODIES HAVING A COMMON LIGHT CHAIN
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Pub. No.: WO/2017/035274 International Application No.: PCT/US2016/048485
Publication Date: 02.03.2017 International Filing Date: 24.08.2016
IPC:
A01K 67/027 (2006.01) ,A61K 39/395 (2006.01)
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
K
ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67
Rearing or breeding animals, not otherwise provided for; New breeds of animals
027
New breeds of vertebrates
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
Applicants:
CRYSTAL BIOSCIENCE INC. [US/US]; 3911 Sorrento Valley Boulevard, Suite 110 San Diego, California 92121, US
Inventors:
HARRIMAN, William Don; US
ETCHES, Robert; US
LEIGHTON, Philip A.; US
Agent:
KEDDIE, James S.; US
Priority Data:
62/210,92627.08.2015US
Title (EN) TRANSGENIC ANIMAL FOR PRODUCTION OF ANTIBODIES HAVING A COMMON LIGHT CHAIN
(FR) ANIMAL TRANSGÉNIQUE POUR LA PRODUCTION D'ANTICORPS AYANT UNE CHAÎNE LÉGÈRE COMMUNE
Abstract:
(EN) This disclosure provides, among other things, a transgenic animal and a method of using the same to make antibodies that have a common light chain. In certain embodiments, the transgenic animal may comprising a genome comprising a common light chain transgene, wherein the common light chain transgene comprises a non-immunoglobulin light-chain promoter and a common light-chain coding sequence. In certain embodiments, the common light chain is constitutively expressed.
(FR) La présente invention concerne, entre autres choses, un animal transgénique et un procédé d'utilisation de celui-ci pour la fabrication d'anticorps qui ont une chaîne légère commune. Dans certains modes de réalisation, l'animal transgénique peut comprendre un génome comprenant un transgène de chaîne légère commune, le transgène de chaîne légère commune comprenant un promoteur de chaîne légère non-immunoglobuline et une séquence de codage de chaîne légère commune. Dans certains modes de réalisation, la chaîne légère commune est exprimée de manière constitutive.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)