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1. (WO2017035271) THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF

Pub. No.:    WO/2017/035271    International Application No.:    PCT/US2016/048477
Publication Date: Fri Mar 03 00:59:59 CET 2017 International Filing Date: Thu Aug 25 01:59:59 CEST 2016
IPC: C07C 69/74
C07C 61/20
C07C 62/20
C07C 62/22
A61K 31/192
Applicants: GENENTECH, INC.
XENON PHARMACEUTICALS INC.
Inventors: HEMEON, Ivan William
SAFINA, Brian
SUTHERLIN, Daniel
Title: THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF
Abstract:
The invention provides compounds having the general formula (I): (I) and pharmaceutically acceptable salts thereof, wherein the variables RAA, n, ring A, X1, L, m, X2, R2, R3, R4, R5, X, and R6 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.