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1. (WO2017035270) BETA-ALANINE AMINOTRANSFERASES FOR THE PRODUCTION OF 3-HYDROXYPROPIONIC ACID

Pub. No.:    WO/2017/035270    International Application No.:    PCT/US2016/048474
Publication Date: Fri Mar 03 00:59:59 CET 2017 International Filing Date: Thu Aug 25 01:59:59 CEST 2016
IPC: C12N 9/10
C12N 1/16
C12P 7/42
Applicants: NOVOZYMES A/S
TASSONE, Monica
DIANO, Audrey
Inventors: TASSONE, Monica
DIANO, Audrey
Title: BETA-ALANINE AMINOTRANSFERASES FOR THE PRODUCTION OF 3-HYDROXYPROPIONIC ACID
Abstract:
Provided herein are recombinant host cells having an active 3-Hydroxypropionic Acid (3-HP) pathway wherein the host cells comprise a heterologous polynucleotide encoding an aminotransferase of E.C. 2.6.1.19 and wherein the aminotransferase comprises the motif (A,C)-Xn-(GSLS)-Xn-SKA(L/l)(L/l). Also described are methods of making the host cells, and methods using the cells to produce 3-HP and derivatives of 3-HP (e.g., acrylic acid).