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1. (WO2017035252) ENHANCED PRODUCTION OF IMMUNOGLOBULINS
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Pub. No.: WO/2017/035252 International Application No.: PCT/US2016/048436
Publication Date: 02.03.2017 International Filing Date: 24.08.2016
IPC:
C12N 15/85 (2006.01) ,A61K 39/395 (2006.01) ,A01K 67/027 (2006.01)
[IPC code unknown for C12N 15/85][IPC code unknown for A61K 39/395][IPC code unknown for A01K 67/027]
Applicants:
TRIANNI, INC. [US/US]; 1515 5th Avenue San Francisco, CA 94122, US
Inventors:
WABL, Matthias; US
DUONG, Bao; US
Agent:
BRASHEARS, Sarah; US
Priority Data:
62/209,26724.08.2015US
Title (EN) ENHANCED PRODUCTION OF IMMUNOGLOBULINS
(FR) PRODUCTION AMÉLIORÉE D'IMMUNOGLOBULINES
Abstract:
(EN) The present invention provides cells, transgenic animals, including transgenic mammals and particularly rodents, comprising engineered immunoglobulin alleles. Mutations in the alleles are designed to compromise allelic exclusion and have potential to be exploited for the isolation of bispecific antibodies.
(FR) La présente invention concerne des cellules, des animaux transgéniques, y compris des mammifères et, en particulier, des rongeurs transgéniques, comprenant des allèles d'immunoglobulines modifiés. Les mutations dans les allèles sont conçues pour compromettre l'exclusion allélique et elles peuvent être utilisées pour l'isolement d'anticorps bispécifiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)