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1. WO2017035249 - ANTI-DEspR MONOCLONAL ANTIBODY TARGETED THERAPY AND IMAGING FOR CANCER AND STROKE

Publication Number WO/2017/035249
Publication Date 02.03.2017
International Application No. PCT/US2016/048427
International Filing Date 24.08.2016
IPC
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
A61M 37/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
37Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
A61K 49/22 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
22Echographic preparations; Ultrasound imaging preparations
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 16/2863
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2863against receptors for growth factors, growth regulators
C07K 2317/21
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
20characterized by taxonomic origin
21from primates, e.g. man
C07K 2317/24
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
20characterized by taxonomic origin
24containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
C07K 2317/34
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
30characterized by aspects of specificity or valency
34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
Applicants
  • TRUSTEES OF BOSTON UNIVERSITY [US]/[US]
Inventors
  • RUIZ-OPAZO, Nelson
  • HERRERA, Victoria L.M.
Agents
  • EISENSTEIN, Ronald I.
  • RESNICK, David S.
  • FITZGERALD, Mark J.
  • BENN, Susanna C.
  • BRAICH, Ravinderjit S.
  • KARTTUNEN CONTARINO, Leena H.
  • CROSBY, David F.
  • HUFF, Shayne Y.
  • MILLS, Tari W.
  • PTASHKA, Teresa A.
  • SUMMERFORD, Candace M.
  • KLING, Nicole D.
Priority Data
62/208,93724.08.2015US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ANTI-DEspR MONOCLONAL ANTIBODY TARGETED THERAPY AND IMAGING FOR CANCER AND STROKE
(FR) TRAITEMENT CIBLÉ PAR ANTICORPS MONOCLONAL ANTI-DESPR ET IMAGERIE POUR CANCER ET AVC
Abstract
(EN)
Provided herein are novel compositions comprising anti-DEspR antibodies and fragments thereof derived from 6G8G7 and 7C5B2 anti-DEspR variant antibodies, including fully human, composite engineered human, humanized, monoclonal, and polyclonal anti-DEspR antibodies and fragments thereof, and methods of their use in a variety of therapeutic applications. The compositions comprising the anti-DEspR antibodies and fragments thereof described herein are useful in diagnostic and imaging methods, such as DEspR-targeted molecular imaging of angiogenesis, and for companion diagnostic and/or in vivo non-invasive imaging and/or assessments.
(FR)
La présente invention concerne de nouvelles compositions comprenant des anticorps anti-DEspR et des fragments de ceux-ci dérivés d'anticorps variants 6G8G7 et 7C5B2 anti-DEspR comprenant des anticorps anti-DEspR entièrement humains, humains composites obtenus par génie génétique, humanisés, monoclonaux, et polyclonaux et des fragments de ceux-ci, et des méthodes pour les utiliser dans diverses applications thérapeutiques. Les compositions comprenant les anticorps anti-DEspR et les fragments de ceux-ci ci-décrits sont utiles dans les méthodes diagnostiques et d'imagerie, telles que l'imagerie moléculaire ciblée DEspR de l'angiogenèse, et l'imagerie et/ou les évaluations diagnostiques compagnons et/ou non invasives in vivo.
Also published as
Latest bibliographic data on file with the International Bureau