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1. (WO2017035241) ENHANCED PRODUCTION OF IMMUNOGLOBULINS

Pub. No.:    WO/2017/035241    International Application No.:    PCT/US2016/048410
Publication Date: Fri Mar 03 00:59:59 CET 2017 International Filing Date: Thu Aug 25 01:59:59 CEST 2016
IPC: A01K 67/027
A61K 39/395
C07K 16/00
C12N 15/13
Applicants: TRIANNI, INC.
Inventors: WABL, Matthias
KILLEEN, Nigel
Title: ENHANCED PRODUCTION OF IMMUNOGLOBULINS
Abstract:
The present invention provides cells, transgenic animals, including transgenic mammals and particularly rodents, comprising engineered immunoglobulin alleles. Mutations in the alleles are designed to compromise allelic exclusion and have potential to be exploited for the isolation of bispecific antibodies.