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1. (WO2017035185) METHODS AND COMPOSITIONS FOR THE DETECTION OF FC RECEPTOR BINDING ACTIVITY OF ANTIBODIES

Pub. No.:    WO/2017/035185    International Application No.:    PCT/US2016/048307
Publication Date: Fri Mar 03 00:59:59 CET 2017 International Filing Date: Thu Aug 25 01:59:59 CEST 2016
IPC: G01N 33/68
Applicants: UNIVERSITY OF CINCINNATI
Inventors: WOODLE, E., Steve
GIRNITA, Alin, Lucian
Title: METHODS AND COMPOSITIONS FOR THE DETECTION OF FC RECEPTOR BINDING ACTIVITY OF ANTIBODIES
Abstract:
Disclosed are kits and methods for determining the presence or absence of an antibody of interest in a biological sample of a subject. In particular, the methods may detect either pathological or beneficial antibodies. The method may include the step of contacting a biological sample from a subject with a substrate conjugated to an antigen and an Fc receptor operatively linked to a detectable label. Detection of the label may indicate the presence or absence of an antibody of interest.