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|1. (WO2017035181) METHODS AND COMPOSITIONS FOR IMMUNE PROTECTION AGAINST EXTRA-INTESTINAL PATHOGENIC E. COLI|
|Applicants:||GLAXOSMITHKLINE BIOLOGICALS S.A.
JANSSEN PHARMACEUTICALS, INC.
|Inventors:||POOLMAN, Jan, Theunis
ABBANAT, Darren, Robert
YON, Patricia, Ibarra
HERMANS, Peter, Wilhelmus, Maria
KOWARIK, Michael, Thomas
WETTER, Michael, Lukas
KEMMLER, Stefan, Jochen
HAUPTLE, Micha, Andres
|Title:||METHODS AND COMPOSITIONS FOR IMMUNE PROTECTION AGAINST EXTRA-INTESTINAL PATHOGENIC E. COLI|
Compositions and methods are described for inducing an immune response against extra-intestinal pathogenic Escherichia coli (ExPEC) to thereby provide immune protection against diseases associated with ExPEC. In particular, compositions and methods are described for using conjugates of E. coli polysaccharide antigens O25B, O1A, O2, and O6A covalently bound to a detoxified exotoxin A of Pseudomonas aeruginosa (EPA) carrier protein as vaccines for the prevention of invasive ExPEC disease caused by ExPEC serotypes O1A, O2, O6A and O25B.