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1. (WO2017035181) METHODS AND COMPOSITIONS FOR IMMUNE PROTECTION AGAINST EXTRA-INTESTINAL PATHOGENIC E. COLI

Pub. No.:    WO/2017/035181    International Application No.:    PCT/US2016/048278
Publication Date: Fri Mar 03 00:59:59 CET 2017 International Filing Date: Thu Aug 25 01:59:59 CEST 2016
IPC: A61K 39/02
C08B 37/00
A61K 39/00
A61K 39/108
Applicants: GLAXOSMITHKLINE BIOLOGICALS S.A.
JANSSEN PHARMACEUTICALS, INC.
Inventors: POOLMAN, Jan, Theunis
JACQUEMYN, Bert
ABBANAT, Darren, Robert
YON, Patricia, Ibarra
HERMANS, Peter, Wilhelmus, Maria
KOWARIK, Michael, Thomas
WETTER, Michael, Lukas
KEMMLER, Stefan, Jochen
HAUPTLE, Micha, Andres
GAMBILLARA, Veronica
MALLY, Manuela
Title: METHODS AND COMPOSITIONS FOR IMMUNE PROTECTION AGAINST EXTRA-INTESTINAL PATHOGENIC E. COLI
Abstract:
Compositions and methods are described for inducing an immune response against extra-intestinal pathogenic Escherichia coli (ExPEC) to thereby provide immune protection against diseases associated with ExPEC. In particular, compositions and methods are described for using conjugates of E. coli polysaccharide antigens O25B, O1A, O2, and O6A covalently bound to a detoxified exotoxin A of Pseudomonas aeruginosa (EPA) carrier protein as vaccines for the prevention of invasive ExPEC disease caused by ExPEC serotypes O1A, O2, O6A and O25B.