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1. (WO2017035154) MRKA POLYPEPTIDES, ANTIBODIES, AND USES THEREOF

Pub. No.:    WO/2017/035154    International Application No.:    PCT/US2016/048221
Publication Date: Fri Mar 03 00:59:59 CET 2017 International Filing Date: Wed Aug 24 01:59:59 CEST 2016
IPC: A61K 38/00
A61K 39/108
A61K 39/395
C07K 14/26
C07K 16/12
C07K 16/18
Applicants: MEDIMMUNE, LLC
Inventors: WANG, Qun
RAJAN, Saravanan
CHANG, Chew-Shun
HEIDBRINK THOMPSON, Jenny
LIN, Hung-Yu
STOVER, Charles Kendall
PENNINI, Meghan
DALL'ACQUA, William
CHOWDHURY, Partha S.
XIAO, Xiaodong
Title: MRKA POLYPEPTIDES, ANTIBODIES, AND USES THEREOF
Abstract:
The present disclosure provides MrkA binding proteins, e.g., antibodies or antigen binding fragments thereof that bind to MrkA and induce opsonophagocytic killing of Klebsiella (e.g., Klebsiella pneumoniae). The present disclosure also provides methods of reducing Klebsiella (e.g., Klebsiella pneumoniae) or treating or preventing Klebsiella (e.g., Klebsiella pneumoniae) infection in a subject comprising administering MrkA binding proteins, e.g., antibodies or antigen-binding fragments thereof, MrkA polypeptides, immunogenic fragments thereof, or polynucleotides encoding MrkA or immunogenic fragments thereof to the subject.