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1. (WO2017035141) MICROBIAL ORGANISMS FOR CONVERTING ACETYL-COA INTO CROTYL ALCOHOL AND METHODS FOR PRODUCING CROTYL ALCOHOL

Pub. No.:    WO/2017/035141    International Application No.:    PCT/US2016/048197
Publication Date: Fri Mar 03 00:59:59 CET 2017 International Filing Date: Wed Aug 24 01:59:59 CEST 2016
IPC: C12N 1/15
C12N 1/19
C12N 1/21
C12N 15/52
Applicants: WHITE DOG LABS, INC.
Inventors: TRACY, Bryan P.
EYAL, Aharon M.
JONES, Shawn William
WIEDEL, Carrissa A.
Title: MICROBIAL ORGANISMS FOR CONVERTING ACETYL-COA INTO CROTYL ALCOHOL AND METHODS FOR PRODUCING CROTYL ALCOHOL
Abstract:
The present invention provides microorganisms capable of converting acetyl-coA into crotyl alcohol as well as fermentation methods for producing crotyl alcohol, either alone, or in combination with acetone and/or isopropanol. The microorganisms may be genetically engineered to express and/or disrupt one or more of the following enzymes: acetaldehyde dehydrogenase, alcohol dehydrogenase, bifunctional acetaldehyde/alcohol dehydrogenase, aldehyde oxidoreductase, phosphotransacetylase, acetate kinase, CoA-transferase A, CoA-transferase B, acetoacetate decarboxylase, secondary alcohol dehydrogenase, butyryl-CoA dehydrogenase (BCD), and/or trans-2-enoyl-CoA reductase (TER).