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1. (WO2017035119) BLOOD BRAIN BARRIER MODEL IN A 3D CO-CULTURE MICROFLUIDIC SYSTEM
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Pub. No.: WO/2017/035119 International Application No.: PCT/US2016/048138
Publication Date: 02.03.2017 International Filing Date: 23.08.2016
IPC:
G01N 33/48 (2006.01) ,C12N 5/079 (2010.01) ,C12M 1/00 (2006.01) ,C12M 3/00 (2006.01) ,B01L 3/00 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
079
Neural cells
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
M
APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1
Apparatus for enzymology or microbiology
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
M
APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3
Tissue, human, animal or plant cell, or virus culture apparatus
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
L
CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3
Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
Applicants:
NATIONAL UNIVERSITY OF SINGAPORE [SG/SG]; 21 Lower Kent Ridge Road Singapore 119077, SG
MASSACHUSETTS INSTITUTE OF TECHNOLOGY [US/US]; 77 Massachusetts Avenue Cambridge, MA 02139, US
Inventors:
KAMM, Roger Dale; US
MA, Dong Liang; SG
GOH, Eyleen Lay Keow; SG
ADRIANI, Giulia; SG
PAVESI, Andrea; SG
Agent:
CARROLL, Alice, O.; US
Priority Data:
62/209,01324.08.2015US
Title (EN) BLOOD BRAIN BARRIER MODEL IN A 3D CO-CULTURE MICROFLUIDIC SYSTEM
(FR) MODÈLE DE BARRIÈRE HÉMATO-ENCÉPHALIQUE DANS UN SYSTÈME MICROFLUIDIQUE 3D DE CO-CULTURE
Abstract:
(EN) An efficient in-vitro Blood Brain Barrier (BBB) model consisting of the key cells of the BBB - namely, neurons, astrocytes and endothelial cells - is provided, which permits recapitulating the in-vivo BBB and shedding light on contributions from each individual cell type. A microfluidic system for modeling the blood brain barrier comprises an optically transparent substrate, the substrate comprising: (i) at least one fluid channel; (ii) a first gel channel comprising a first gel region; (iii) a second gel channel comprising a second gel region; and (iv) at least one row of posts.
(FR) La présente invention concerne un modèle de barrière hémato-encéphalique (BBB) efficace in vitro consistant en des cellules clés de la BBB - à savoir, des neurones, des astrocytes et des cellules endothéliales - qui permet de récapituler la BBB in vivo et d'apporter des éclaircissements sur des contributionsde chaque type de cellule individuelle. Un système microfluidique pour la modélisation de la barrière hémato-encéphalique comprend un substrat optiquement transparent, ledit substrat comprenant : (i) au moins un canal de fluide ; (ii) un premier canal de gel comprenant une première région de gel ; (iii) un second canal de gel comprenant une seconde région de gel ; et (iv) au moins une rangée de montants.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)