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1. (WO2017035118) TGF BETA RECEPTOR ANTAGONISTS
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Pub. No.: WO/2017/035118 International Application No.: PCT/US2016/048136
Publication Date: 02.03.2017 International Filing Date: 23.08.2016
IPC:
C07D 473/34 (2006.01) ,A61K 31/52 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
473
Heterocyclic compounds containing purine ring systems
26
with an oxygen, sulfur, or nitrogen atom directly attached in position 2 or 6, but not in both
32
Nitrogen atom
34
attached in position 6, e.g. adenine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
52
Purines, e.g. adenine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
BRISTOL-MYERS SQUIBB COMPANY [US/US]; Route 206 and Province Line Road Princeton, New Jersey 08543, US
Inventors:
BORZILLERI, Robert M.; US
FINK, Brian E.; US
HARIKRISHNAN, Lalgudi S.; US
VELAPARTHI, Upender; US
BALIGAR, Vishweshwaraiah; IN
RAHAMAN, Hasibur; IN
WARRIER, Jayakumar Sankara; IN
Agent:
KORSEN, Elliott; US
BELLOMY, Gregory R.; US
BERGEN, Briana C.; US
CHAO, Yuan; US
CLAUSS, Isabelle M.; US
D'AMICO, Stephen C.; US
DELAUNEY, Ashton J.; US
EPPERSON, James; US
FARQUHARSON-TORRES, Serena; US
FRANK, Eve; US
GOLIAN, Paul D.; US
GREENBLATT, Gary D.; US
GUO, Z. Angela; US
HADAD, Henry; US
HAI, Bing; US
JACOBSEN, Barry H.; US
LIU, Hong; US
LU, Yong; US
MINGO, Pamela A.; US
PARLET, Nickki L.; US
VANATTEN, Mary K.; US
VOLLES, Warren K.; US
WALSH, Brian J.; US
Priority Data:
62/209,53125.08.2015US
Title (EN) TGF BETA RECEPTOR ANTAGONISTS
(FR) ANTAGONISTES DU RÉCEPTEUR TGF BÊTA
Abstract:
(EN) The invention relates generally to compounds of formula (I) that modulate the activity of TGFβR-1 and TGFβR-2, pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.
(FR) L'invention concerne, de manière générale, des composés de formule (I) qui modulent l'activité du TGFβR-1 et du TGFβR-2, des compositions pharmaceutiques contenant lesdits composés et des méthodes de traitement de troubles prolifératifs et de troubles liés à une dérégulation de l'apoptose, tels que le cancer, à l'aide des composés de l'invention.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)