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1. (WO2017035114) BENZIMIDAZOLE DERIVATIVES USEFUL AS CB-1 INVERSE AGONISTS
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Pub. No.: WO/2017/035114 International Application No.: PCT/US2016/048130
Publication Date: 02.03.2017 International Filing Date: 23.08.2016
IPC:
A01N 57/00 (2006.01) ,A61K 31/665 (2006.01)
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
N
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
57
Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
66
Phosphorus compounds
665
having oxygen as a ring hetero atom, e.g. fosfomycin
Applicants:
MACIELAG, Mark J. [US/US]; US (US)
JANSSEN PHARMACEUTICA NV [BE/BE]; Turnhoutseweg 30 B-2340 Beerse, BE
Inventors:
MACIELAG, Mark J.; US
ZHANG, Rui; US
ZHANG, Yue-Mei; US
ZHU, Bin; US
PARKER, Michael H.; US
LUDOVICI, Donald W.; US
PARKS, Daniel J.; US
DECORTE, Bart L.; US
GRECO, Michael N.; US
Agent:
DEBERARDINE, Robert; US
DODD, Thomas; US
Priority Data:
62/209,38125.08.2015US
62/233,65528.09.2015US
Title (EN) BENZIMIDAZOLE DERIVATIVES USEFUL AS CB-1 INVERSE AGONISTS
(FR) DÉRIVÉS DE BENZIMIDAZOLE UTILES À TITRE D'AGONISTES INVERSES DE CB-1
Abstract:
(EN) The present invention is directed to benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions mediated by the CB-1 receptor; more particularly, use in the treatment of disorders and conditions responsive to inverse agonism of the CB-1 receptor. More particularly, the compounds of the present invention are useful in the treatment of metabolic disorders.
(FR) L’invention concerne des dérivés de benzimidazole, des compositions pharmaceutiques les contenant et leur utilisation dans le traitement des troubles et des affections médiés par le récepteur CB-1 ; plus particulièrement, leur utilisation dans le traitement des troubles et des affections sensibles à l'agonisme inverse du récepteur CB-1. Plus particulièrement, les composés selon l'invention sont utiles dans le traitement des troubles métaboliques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)