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1. (WO2017035112) DOSE DIVIDER SYRINGE
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CLAIMS

1. A dose divider for a syringe, the dose divider comprising:

a base including a flange that extends at least partly in a radial direction; and at least one column extending away from the base along a longitudinal direction, the longitudinal direction being perpendicular to the radial direction,

the at least one column including a proximal end and a distal end opposite the proximal end, the proximal end of the at least one column being coupled to the base, and the at least one column including a sacrificial portion coupled to a frangible link.

2. The dose divider of Claim 1 , wherein the at least one column is coupled to the base via the frangible link.

3. The dose divider of Claim 2, wherein the at least one column further includes a fixed portion coupled to the sacrificial portion via the frangible link, the fixed portion being coupled to the base.

4. The dose divider of any of Claims 1-3, wherein the base further includes a wall extending away from the flange along the longitudinal direction, and

wherein the proximal end of the at least one column is coupled to the base via the wall.

5. The dose divider of Claim 4, wherein the wall is an annular wall, and an interior surface of the annular wall defines a recess therein.

6. The dose divider of Claim 1 , wherein the at least one column includes a first column and a second column, a length of the first column along the longitudinal direction being greater than a length of the second column along the longitudinal direction.

7. The dose divider of Claim 6, wherein the at least one column further includes a third column, the length of the second column along the longitudinal direction being greater than a length of the third column along the longitudinal direction.

8. The dose divider of Claim 1 , wherein the at least one column includes a first pair of columns, and

wherein a first column and a second column compose the first pair of columns, a length of the first column along the longitudinal direction being equal to a length of the second column along the longitudinal direction.

9. The dose divider of Claim 8, wherein the first column is diametrically opposed to the second column across the base.

10. The dose divider of Claim 8, wherein the at least one column further includes a second pair of columns,

wherein a third column and a fourth column compose the second pair of columns, a length of the third column along the longitudinal direction being equal to a length of the fourth column along the longitudinal direction, and

wherein the length of the first column is less than the length of the third column.

11. The dose divider of Claim 10, wherein the third column is diametrically opposed to the fourth column across the base, and the third column is arranged between the first column and the second column about a circumferential direction.

12. The dose divider of Claim 10, wherein the at least one column further includes a third pair of columns,

wherein a fifth column and a sixth column compose the third pair of columns, a length of the fifth column along the longitudinal direction being equal to a length of the sixth column along the longitudinal direction, and

wherein the length of the third column is less than the length of the fifth column.

13. The dose divider of Claim 12, wherein the fifth column is diametrically opposed to the sixth column across the base, and the fifth column is arranged between the first column and the third column about a circumferential direction.

14. The dose divider of Claim 1, wherein a cross-sectional area of the sacrificial portion perpendicular to the longitudinal direction is greater than a cross-sectional area of the frangible link perpendicular to the longitudinal direction.

15. The dose divider of Claim 1 , wherein the at least one column defines a concavity facing toward a longitudinal axis of the dose divider along the radial direction.

16. A syringe, comprising:

a barrel having an internal surface defining an internal bore therein;

a plunger having a distal end disposed within the internal bore of the barrel, and a proximal end disposed outside the internal bore of the barrel, the proximal end of the plunger being opposite the distal end of the plunger along a longitudinal direction; and

a dose divider configured to bear on the barrel in response to translation of the plunger relative to the barrel along the longitudinal direction, the dose divider including a base including a flange that extends at least partly in a radial direction, the radial direction being perpendicular to the longitudinal direction; and

at least one column extending away from the base along the longitudinal direction,

the at least one column including a proximal end and a distal end opposite the proximal end, the proximal end of the at least one column being coupled to the base, and the at least one column including a sacrificial portion coupled to a frangible link.

17. The syringe of Claim 16, wherein

the base of the dose divider defines an axis along the longitudinal direction, the at least one column has a radial dimension from the axis to a point on the distal end of the at least one column, and

the radial dimension of the at least one column is greater than a radial dimension from the axis to the internal bore of the barrel.

18. The syringe of either Claims 16 or 17, wherein

the barrel further includes a barrel flange disposed near a proximal end of the barrel, the barrel flange extending away from the barrel at least partly in the radial direction, and the radial dimension of the at least one column is less than or equal to a radial dimension from the axis to a point on a periphery of the barrel flange.

19. The syringe of Claim 18, wherein a distal surface of the at least one column faces the barrel flange, such that translation of the dose divider toward the barrel flange over a prescribed distance results in the distal surface of the at least one column bearing on the barrel flange.

20. The syringe of Claim 16, wherein

a distal end of the barrel defines an outlet port, and

the plunger includes a vial having an internal volume, the internal volume being configured to contain a fluid, the internal volume of the vial being in fluid communication with the outlet port of the barrel.

21. A method for delivering a material from a syringe, the method comprising: breaking away a first sacrificial portion from a first column of a dose divider at a first frangible link;

installing the dose divider on a proximal end of a plunger, such that a radially inner surface of a remaining column of the dose divider faces the plunger;

expelling a first portion of the material from the syringe by bearing a distal surface of a dose divider flange against a proximal surface of the plunger to translate the plunger from a first position to a second position relative to a barrel along a longitudinal axis of the plunger; bearing a distal end of the dose divider against the barrel; and

expelling a second portion of the material from the syringe by translating the plunger from the second position to a third position relative to the barrel along the longitudinal axis.

22. The method of Claim 21 , wherein the remaining column is the first column after the breaking away of the first sacrificial portion.

23. The method of Claim 21 , wherein the breaking away the first sacrificial portion includes breaking away an entirety of a first column from the dose divider, and the remaining column is a second column of the dose divider, the second column being distinct from the first column.

24. The method of Claim 21, further comprising rotating the dose divider relative to the barrel about a circumferential direction with respect to a longitudinal axis of the plunger, wherein the rotating the dose divider relative to the barrel occurs before the expelling the second portion of the material from the syringe.

25. The method of Claim 24, wherein the remaining column is a first remaining column, and the distal end of the dose divider is a distal end of the first remaining column, the method further comprising bearing a distal end of a second remaining column of the dose divider against the barrel,

wherein a length of the second remaining column along a longitudinal direction is shorter than a length of the first remaining column along the longitudinal direction, the longitudinal direction being parallel to the longitudinal axis of the plunger.

26. The method of Claim 21 , further comprising delivering the first portion of the material and the second portion of the material into an internal volume of the plunger before expelling the first portion of the material from the syringe.

27. The method of Claim 26, wherein the expelling the first portion of the material from the syringe includes expelling the first portion of the material from the internal volume of the plunger.

28. The method of Claim 26, wherein the plunger includes a removable vial, and the internal volume of the plunger includes an intemal volume of the removable vial.