Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2017035082) ALDEHYDE CONJUGATES AND USES THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/035082 International Application No.: PCT/US2016/048064
Publication Date: 02.03.2017 International Filing Date: 22.08.2016
IPC:
A61K 31/136 (2006.01) ,A61K 31/517 (2006.01) ,A61Q 19/08 (2006.01)
[IPC code unknown for A61K 31/136][IPC code unknown for A61K 31/517][IPC code unknown for A61Q 19/08]
Applicants:
ALDEYRA THERAPEUTICS, INC. [US/US]; 131 Hartwell Avenue, Suite 320 Lexington, Massachusetts 02421, US
Inventors:
BRADY, Todd; US
YOUNG, Scott; US
KINNEY, William A.; US
Agent:
REID, Andrea L.C.; US
ROCCO, Vincent P.; US
ARICO, Joseph W.; US
OH, Euk Charlie; US
DECHERT LLP; One International Place, 40th Floor 100 Oliver Street Boston, Massachusetts 02110-2605, US
Priority Data:
62/208,27821.08.2015US
62/315,45530.03.2016US
62/347,46408.06.2016US
Title (EN) ALDEHYDE CONJUGATES AND USES THEREOF
(FR) CONJUGUÉS D’ALDÉHYDE ET LEURS UTILISATIONS
Abstract:
(EN) The present invention provides compounds and methods of use thereof for the treatment, prevention, and/or reduction of a risk of a disease, disorder, or condition in which aldehyde toxicity is implicated in the pathogenesis, including ocular disorders, skin disorders, conditions associated with injurious effects from blister agents, and autoimmune, inflammatory, neurological and cardiovascular diseases by the use of a primary amine to scavenge toxic aldehydes, such as MDA and HNE.
(FR) La présente invention concerne des composés et des méthodes d'utilisation de ces composés dans le traitement, la prévention et/ou la réduction d'un risque d'une maladie, d'un trouble ou d'un état dans lequel une toxicité d'aldéhyde est impliquée dans la pathogenèse, y compris des troubles oculaires, des troubles cutanés, des états associés aux effets nuisibles d'agents vésicants, et des maladies auto-immunes, inflammatoires, neurologiques et cardiovasculaires, par l'utilisation d'une amine primaire pour piéger des aldéhydes toxiques, comme la MDA et la HNE.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)