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1. (WO2017035077) DEUTERATED COMPOUNDS AND USES THEREOF
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Pub. No.: WO/2017/035077 International Application No.: PCT/US2016/048054
Publication Date: 02.03.2017 International Filing Date: 22.08.2016
IPC:
A61K 31/535 (2006.01)
[IPC code unknown for A61K 31/535]
Applicants:
ALDEYRA THERAPEUTICS, INC. [US/US]; 131 Hartwell Avenue, Suite 320 Lexington, MA 02421, US
Inventors:
BRADY, Todd; US
YOUNG, Scott; US
KINNEY, William, A.; US
MACDONALD, Susan; US
Agent:
REID, Andrea, L.C.; US
ROCCO, Vincent P.; US
ARICO, Joseph W.; US
OH, Euk Charlie; US
DECHERT LLP; One International Place, 40th Floor 100 Oliver Street Boston, Massachusetts 02110-2605, US
Priority Data:
62/208,22321.08.2015US
Title (EN) DEUTERATED COMPOUNDS AND USES THEREOF
(FR) COMPOSÉS DEUTÉRÉS ET LEURS UTILISATIONS
Abstract:
(EN) The present invention provides for the treatment, prevention, and/or reduction of a risk of a disease, disorder, or condition in which aldehyde toxicity is implicated in the pathogenesis, including ocular disorders, skin disorders, conditions associated with injurious effects from blister agents, and autoimmune, inflammatory, neurological and cardiovascular diseases by the use of a primary amine to scavenge toxic aldehydes, such as MDA and HNE.
(FR) La présente invention concerne le traitement, la prévention et/ou la réduction d'un risque d'une maladie, d'un trouble ou d'un état dans lequel une toxicité d'aldéhyde est impliquée dans la pathogenèse, y compris des troubles oculaires, des troubles cutanés, des états associés aux effets nuisibles d'agents vésicants, et des maladies auto-immunes, inflammatoires, neurologiques et cardiovasculaires, par l'utilisation d'une amine primaire pour piéger des aldéhydes toxiques, tels que MDA et HNE.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)