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1. (WO2017035010) COMPOSITIONS AND METHODS FOR USE IN COMBINATION FOR THE TREATMENT AND DIAGNOSIS OF AUTOIMMUNE DISEASES
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Pub. No.: WO/2017/035010 International Application No.: PCT/US2016/047857
Publication Date: 02.03.2017 International Filing Date: 19.08.2016
IPC:
A61K 31/00 (2006.01) ,A61P 1/00 (2006.01) ,C12Q 1/68 (2006.01)
[IPC code unknown for A61K 31][IPC code unknown for A61P 1][IPC code unknown for C12Q 1/68]
Applicants:
THE CHILDREN'S HOSPITAL OF PHILADELPHIA [US/US]; 34th Street and Civic Center Boulevard Philadelphia, PA 19104, US
Inventors:
HAKONARSON, Hakon; US
LI, Yun, Rose; US
KEATING, Brendan; US
Agent:
RIGAUT, Kathleen, D.; US
HERRELL, Roger, W.; US
HAGAN, Patrick, J.; US
PIPER, Donald, R., Jr.; US
PACE, Vincent, T.; US
Priority Data:
62/208,38321.08.2015US
62/320,40008.04.2016US
Title (EN) COMPOSITIONS AND METHODS FOR USE IN COMBINATION FOR THE TREATMENT AND DIAGNOSIS OF AUTOIMMUNE DISEASES
(FR) COMPOSITIONS ET MÉTHODES D'UTILISATION EN ASSOCIATION DESTINÉES AU TRAITEMENT ET AU DIAGNOSTIC DE MALADIES AUTO-IMMUNES
Abstract:
(EN) This disclosure provides new genetic targets, diagnostic methods, and therapeutic treatment regimens for multiple autoimmune disorders, including pediatric autoimmune disorders that are co-inherited and genetically shared. The disclosure, for example, provides methods of diagnosing or determining a susceptibility for one or more autoimmune diseases and methods of determining treatment protocols for patients with one or more autoimmune diseases based on determining if the patients have genetic alterations in particular genes.
(FR) La présente invention concerne des nouvelles cibles génétiques, des nouvelles méthodes diagnostiques et des nouveaux régimes de traitement thérapeutique pour de nombreuses maladies auto-immunes, notamment des maladies auto-immunes pédiatriques qui sont héritées simultanément et partagées génétiquement. La présente invention, par exemple, concerne des méthodes de diagnostic ou de détermination d'une prédisposition à une ou plusieurs maladies auto-immunes et des méthodes de détermination de protocoles de traitement pour des patients atteints d'une ou de plusieurs maladies auto-immunes basées sur la détermination du fait que les patients possèdent ou non des altérations génétiques de gènes particuliers.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)