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1. (WO2017035009) CATIONIC LIPOSOMES FOR CANCER IMMUNOTHERAPY
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Pub. No.: WO/2017/035009 International Application No.: PCT/US2016/047851
Publication Date: 02.03.2017 International Filing Date: 19.08.2016
IPC:
C07K 17/02 (2006.01) ,A61K 9/127 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
17
Carrier-bound or immobilised peptides; Preparation thereof
02
Peptides being immobilised on, or in, an organic carrier
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
127
Liposomes
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
SERDA, Rita, Elena [US/US]; US
MERAZ, Ismail, Mustafa [US/US]; US
THE METHODIST HOSPITAL [US/US]; 6565 Fannin MS D-200 Houston, TX 77030, US
Inventors:
SERDA, Rita, Elena; US
MERAZ, Ismail, Mustafa; US
Agent:
PERDOK, Monique, M.; US
ARORA, Suneel; US
BEEKMAN, Marvin L.; US
BIANCHI, Timothy E.; US
BLACK, David W.; US
GOULD, James R.; US
MCCRACKIN, Ann M.; US
SCHEER, Bradley W.; US
WOO, Justin N.; US
Priority Data:
62/208,34421.08.2015US
Title (EN) CATIONIC LIPOSOMES FOR CANCER IMMUNOTHERAPY
(FR) LIPOSOMES CATIONIQUES POUR L'IMMUNOTHÉRAPIE DU CANCER
Abstract:
(EN) Disclosed are positively-charged, cytotoxic nanoparticle compositions comprising immune modulators (such as the toll-like receptor (TLR)-4 ligand, monophosphoryl lipid (MPL)-A), and Interleukin (IL)-12)), which exhibit enhanced uptake by mammalian cancer cells, and cause increased cancer cell death and/or an increased release of cancer antigens following direct injection to populations of cancer or tumor cells. Also disclosed are nanoparticle-vectored, immunomodulatory compositions that stimulate antigen presenting immune cells and T cells, and support the development of anti-cancer immunity in mammalian hosts. The disclosed cationic liposomes represent an important advance in the area of cancer immunotherapeutics.
(FR) L'invention concerne des compositions nanoparticulaires cytotoxiques, chargées positivement, comprenant des immunomodulateurs (tels que le ligand du récepteur de type toll (TLR)-4, le monophosphoryl-lipide (MPL)-A) et l'interleukine (IL)-12)), qui présentent une meilleure absorption par des cellules cancéreuses mammifères et qui provoquent une mort accrue des cellules cancéreuses et/ou une libération accrue d'antigènes du cancer après l'injection directe dans des populations de cellules cancéreuses ou tumorales. L'invention concerne également des compositions immunomodulatoires vectorisées par des nanoparticules, qui stimulent des cellules immunes présentatrices d'antigène et des lymphocytes T présentant des antigènes et soutiennent le développement d'une immunité anti-cancer dans des hôtes mammifères. Les liposomes cationiques divulgués représentent une avancée importante dans le domaine des agents immunothérapeutiques du cancer.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)