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1. (WO2017034984) IDENTIFICATION OF ADDITIONAL ANTI-PERSISTER ACTIVITY AGAINST BORRELIA BURGDORFERI FROM AN FDA DRUG LIBRARY

Pub. No.:    WO/2017/034984    International Application No.:    PCT/US2016/047784
Publication Date: Fri Mar 03 00:59:59 CET 2017 International Filing Date: Sat Aug 20 01:59:59 CEST 2016
IPC: C12N 1/20
A61K 31/409
A61K 31/4439
A61K 31/485
A61K 31/497
Applicants: THE JOHNS HOPKINS UNIVERSITY
Inventors: ZHANG, Ying
FENG, Jie
Title: IDENTIFICATION OF ADDITIONAL ANTI-PERSISTER ACTIVITY AGAINST BORRELIA BURGDORFERI FROM AN FDA DRUG LIBRARY
Abstract:
The presently disclosed subject matter provides methods for inhibiting the growth and/or survival of bacteria from the Borrelia genus and for treating Lyme disease. These methods include agents that inhibit the glutathione/γ-glutamyl pathway and are involved in protection against free radical damage, cell membranes, energy production, and/or reactive oxygen species production. Many of these compounds are antimicrobial agents (antibiotics, antivirals, antifungals, anthelmintics or antiparasitics) and drugs used for treating other non-infectious conditions.