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1. (WO2017034927) HOMOALLYLAMINES AS FORMALDEHYDE-RESPONSIVE TRIGGERS
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Pub. No.: WO/2017/034927 International Application No.: PCT/US2016/047580
Publication Date: 02.03.2017 International Filing Date: 18.08.2016
IPC:
G01N 21/64 (2006.01) ,C09K 11/06 (2006.01) ,C07C 211/21 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21
Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible, or ultra-violet light
62
Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63
optically excited
64
Fluorescence; Phosphorescence
C CHEMISTRY; METALLURGY
09
DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
K
MATERIALS FOR APPLICATIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
11
Luminescent, e.g. electroluminescent, chemiluminescent, materials
06
containing organic luminescent materials
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
211
Compounds containing amino groups bound to a carbon skeleton
01
having amino groups bound to acyclic carbon atoms
20
of an acyclic unsaturated carbon skeleton
21
Monoamines
Applicants:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street, 12th Floor Oakland, California 94607, US
Inventors:
CHANG, Christopher J.; US
BREWER, Thomas Francis; US
CHAN, Jefferson; US
Agent:
BORDEN, Paula A.; US
Priority Data:
62/208,30521.08.2015US
Title (EN) HOMOALLYLAMINES AS FORMALDEHYDE-RESPONSIVE TRIGGERS
(FR) HOMOALLYLAMINES EN TANT QUE DÉCLENCHEURS SENSIBLES AU FORMALDÉHYDE
Abstract:
(EN) Probes for formaldehyde (FA) including a homoallylamine trigger group attached to a detectable moiety are provided. Aspects of the probes include luminogenic or fluorogenic probes, such as a probe including a quencher in energy-receiving proximity to a fluroophore. Also provided are methods of using the probes for sensitive and bioorthogonal detection of FA in a sample. Aspects of the methods include selectively reacting the probe with the formaldehyde in the sample to a release (e.g., via a 2-aza- Cope rearrangement) a reporter group comprising a detectable moiety. Aspects of the methods detecting formaldehyde in a cell, tissue, organ or fluid in a subject. Also provided are compositions and kits including the subject probes that find use in practicing various embodiments of the subject methods.
(FR) L'invention concerne des sondes pour formaldéhyde (FA) comprenant un groupe de déclenchement en homoallylamine fixé à une fraction détectable. Des aspects des sondes comprennent des sondes fluorogènes ou luminogènes, tel qu'une sonde comprenant un extincteur de luminescence en proximité de réception d'énergie d'un fluorophore. L'invention concerne également des procédés d'utilisation des sondes pour la détection sensible et bio-orthogonale de FA dans un échantillon. Des aspects des procédés consistent à faire réagir de façon sélective la sonde avec le formaldéhyde dans l'échantillon pour une libération (par exemple, par l'intermédiaire d'un réarrangement 2-aza de Cope) d'un groupe rapporteur comprenant une fraction détectable. Des aspects des procédés permettant de détecter du formaldéhyde dans une cellule, un tissu, un organe ou un fluide d'un sujet. L'invention concerne également des compositions et des kits comprenant les sondes objets qui trouvent une utilisation dans la réalisation de divers modes de réalisation des procédés de l'invention.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)