Search International and National Patent Collections

1. (WO2017034919) COMPOSITIONS AND METHODS FOR SELECTIVELY INHIBITING INTESTINAL CARBOXYLESTERASE 2 ENZYME ACTIVITY

Pub. No.:    WO/2017/034919    International Application No.:    PCT/US2016/047544
Publication Date: Fri Mar 03 00:59:59 CET 2017 International Filing Date: Fri Aug 19 01:59:59 CEST 2016
IPC: A61P 1/12
A61K 31/00
A61K 31/35
A61K 31/352
A61P 1/00
Applicants: THE METHODIST HOSPITAL
Inventors: KONG, Ren
ZHAO, Hong
WONG, Stephen T.C.
Title: COMPOSITIONS AND METHODS FOR SELECTIVELY INHIBITING INTESTINAL CARBOXYLESTERASE 2 ENZYME ACTIVITY
Abstract:
A method for treating diarrhea induced by a chemotherapy agent by administering a carboxylesterase 2 (CES2) inhibitor, i.e., hesperetin, naringenin, or 2',4'-dihydroxychalcone. Also disclosed is a method for treating cancer by administering a chemotherapy agent together with hesperetin, naringenin, or 2',4'-dihydroxychalcone. Furthermore, a composition for treating cancer is provided, the composition containing a chemotherapy agent and hesperetin, naringenin, or 2',4'-dihydroxychalcone.