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1. (WO2017034916) PD-L1 ("PROGRAMMED DEATH-LIGAND 1") ANTIBODIES

Pub. No.:    WO/2017/034916    International Application No.:    PCT/US2016/047528
Publication Date: Fri Mar 03 00:59:59 CET 2017 International Filing Date: Fri Aug 19 01:59:59 CEST 2016
IPC: A61K 39/395
C07K 16/28
Applicants: ELI LILLY AND COMPANY
Inventors: LI, Yiwen
LUDWIG, Dale Lincoln
MOLKENTHIN, Vera
SHEN, Juqun
SNAVELY, Marshall Davenport
Title: PD-L1 ("PROGRAMMED DEATH-LIGAND 1") ANTIBODIES
Abstract:
The present disclosure relates to antibodies that bind human programmed cell death 1 ligand 1 (PD-L1 ), useful for treating solid and hematological tumors alone and in combination with chemotherapy and other cancer therapeutics. Said antibodies have specific variable chain sequences. According to the experimental results, they demonstrate superior association rates that translate into better in vivo activity and T cell response to a tumor cells.