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1. (WO2017034833) METHODS AND MATERIALS FOR EXPANDING ANTIGEN-SPECIFIC T CELLS IN CULTURE

Pub. No.:    WO/2017/034833    International Application No.:    PCT/US2016/046816
Publication Date: Fri Mar 03 00:59:59 CET 2017 International Filing Date: Sat Aug 13 01:59:59 CEST 2016
IPC: C12N 5/071
C12N 5/0783
C07K 16/28
Applicants: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
UNIVERSITY OF WASHINGTON
Inventors: COHEN, Peter A.
GENDLER, Sandra J.
PATHANGEY, Latha B.
MCCURRY, Dustin B.
GORMAN, Jessica E.
DISIS, Mary L.
Title: METHODS AND MATERIALS FOR EXPANDING ANTIGEN-SPECIFIC T CELLS IN CULTURE
Abstract:
This document provides methods and materials for expanding antigen-specific T cells (e.g., antigen-specific CD4+ T cells and/or antigen-specific CD8+ T cells) in culture. For example, methods and materials for performing a polyclonal stimulation step for a particular duration (e.g., from about 1 hour to about 48 hours) to increase the expansion of T cells having a desired antigen specificity are provided.