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1. (WO2017034770) MULTISPECIFIC ANTIBODY PLATFORM AND RELATED METHODS

Pub. No.:    WO/2017/034770    International Application No.:    PCT/US2016/045325
Publication Date: Fri Mar 03 00:59:59 CET 2017 International Filing Date: Thu Aug 04 01:59:59 CEST 2016
IPC: A61K 39/395
C07K 16/46
C12N 15/13
Applicants: BISON THERAPEUTICS INC.
Inventors: ZHANG, Wenjun
Title: MULTISPECIFIC ANTIBODY PLATFORM AND RELATED METHODS
Abstract:
Novel multispecific antibody platform, multispecific antibodies and a method to make the antibodies is disclosed here. The CH3 domain harboring polypeptide chains of the Fc-regions are modified by increasing the positive charge of one chain and negative charge of another chain. Heterodimer formation in cotransfection with the modified chains is comparable to formation of wild type antibodies when same cell line is transfected with wild type polypeptides. Moreover, the modification provides a simple one step purification of the heterodimers.