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1. (WO2017034631) SUBSTITUTED 1-ARYLALKYL-4-ACYLAMINOPIPERIDINE COMPOUNDS AND METHODS OF PRODUCING AND USING THESAME
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2017/034631 International Application No.: PCT/US2016/030649
Publication Date: 02.03.2017 International Filing Date: 04.05.2016
IPC:
A61K 31/445 (2006.01) ,C07D 211/56 (2006.01) ,C07D 211/58 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
445
Non-condensed piperidines, e.g. piperocaine
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
211
Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04
with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06
having no double bonds between ring members or between ring members and non-ring members
36
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
56
Nitrogen atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
211
Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04
with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06
having no double bonds between ring members or between ring members and non-ring members
36
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
56
Nitrogen atoms
58
attached in position 4
Applicants:
ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA [US/US]; University Services Annex 4th Floor PO Box 210300A Tucson, AZ 85721, US
Inventors:
VARDANYAN, Ruben, S.; US
HRUBY, Victor, J.; US
Agent:
CHA, Don, D.; US
Priority Data:
14/834,18524.08.2015US
Title (EN) SUBSTITUTED 1-ARYLALKYL-4-ACYLAMINOPIPERIDINE COMPOUNDS AND METHODS OF PRODUCING AND USING THESAME
(FR) COMPOSÉS SUBSTITUÉS DE 1-ARYLALKYL-4-ACYLAMINOPIPÉRIDINE, ET PROCÉDÉS DE PRODUCTION ET MÉTHODES D'UTILISATION ASSOCIÉS
Abstract:
(EN) The present invention provides using a substituted l-arylalkyl-4-acylaminopiperidine compound of Formula I: to treat various clinical conditions including, but not limited to, hemorrhagic shock, nicotine withdrawal symptoms, gastrointestinal side effects of opioids, cancer therapy, epithelial wounds, herpes zoster infection, or opioid-induced pruritus. In compound of Formula I, R1 is C1-10alkyl, C1-10 haloalkyl, optionally substituted aryl, or optionally substituted heteroaryl; R2 is C1-6 alkylene; Y is optionally substituted aryl, optionally substituted heteroaryl, or a moiety of the formula -C(=0)-X1, wherein X1 is -OR3 or -NR4R5, where each of R3, R4 and R5 is H or CLIO alkyl.
(FR) La présente invention concerne l'utilisation d'un composé substitué de 1-arylalkyl-4-acylaminopipéridine de Formule I : pour traiter divers états cliniques comprenant, mais sans y être limités, le choc hémorragique, les symptômes de sevrage à la nicotine, les effets indésirables gastro-intestinaux des opioïdes, le traitement du cancer, les plaies épithéliales, le zona, ou le prurit induit par un opioïde. Dans le composé de formule I, R1 est un alkyle en C1-10, un haloalkyle en C1-10, un aryle éventuellement substitué ou un hétéroaryle éventuellement substitué ; R2 est un alkylène en C1-6 ; Y est un aryle éventuellement substitué, un hétéroaryle éventuellement substitué ou un groupement de formule -C(=0)-X1, où X1 est -OR3 ou -NR4R5, chacun des R3, R4 et R5 étant un H ou un alkyle en C1-10.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)