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1. (WO2017034459) NEW USE
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Pub. No.: WO/2017/034459 International Application No.: PCT/SE2016/050786
Publication Date: 02.03.2017 International Filing Date: 23.08.2016
IPC:
C12N 5/071 (2010.01)
[IPC code unknown for C12N 5/071]
Applicants:
DIAMYD MEDICAL AB [SE/SE]; Kungsgatan 29 111 56 Stockholm, SE
Inventors:
ESSEN-MÖLLER, Anders; SE
Agent:
ZACCO SWEDEN AB; P.O. Box 5581 Valhallavägen 117N 114 85 Stockholm, SE
Priority Data:
SE1530121-123.08.2015SE
Title (EN) NEW USE
(FR) NOUVELLE UTILISATION
Abstract:
(EN) The present invention relates to a method for in vitro cultivation of hematopoietic and/or mesenchymal cells, wherein said cells are cultivated in a cultivation medium comprising gamma- aminobutyric acid (GABA) or a GABA receptor agonist, to cells obtained by such a method and therapeutic use of such cells in methods of treatment of autoimmune, inflammatory or allergic disorder. The invention further relates to pharmaceutical compositions comprising the cells and cultivation media for use in the method according to the invention.
(FR) La présente invention concerne un procédé de culture in vitro de cellules hématopoïétiques et/ou mésenchymateuses, lesdites cellules étant cultivées dans un milieu de culture comprenant de l'acide gamma-aminobutyrique (GABA) ou un agoniste du récepteur de GABA, les cellules obtenues par un tel procédé et l'utilisation thérapeutique de ces cellules dans des méthodes de traitement de troubles auto-immuns, inflammatoires ou allergiques. L'invention concerne en outre des compositions pharmaceutiques comprenant les cellules et les milieux de culture destinées à être utilisées dans la méthode selon l'invention.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)