Search International and National Patent Collections

1. (WO2017034407) ZIC1 AND GHSR, MOLECULAR DIAGNOSTIC MARKERS FOR HPV-INDUCED INVASIVE CANCERS, NONHPV-INDUCED GYNAECOLOGICAL AND ANOGENITAL CANCERS AND THEIR HIGH-GRADE PRECURSOR LESIONS

Pub. No.:    WO/2017/034407    International Application No.:    PCT/NL2016/050593
Publication Date: Fri Mar 03 00:59:59 CET 2017 International Filing Date: Fri Aug 26 01:59:59 CEST 2016
IPC: C12Q 1/68
Applicants: SELF-SCREEN B.V.
Inventors: HESSELINK, Albertus Theodorus
Title: ZIC1 AND GHSR, MOLECULAR DIAGNOSTIC MARKERS FOR HPV-INDUCED INVASIVE CANCERS, NONHPV-INDUCED GYNAECOLOGICAL AND ANOGENITAL CANCERS AND THEIR HIGH-GRADE PRECURSOR LESIONS
Abstract:
The invention relates to method for detecting HPV-induced high-grade precancerous lesions, HPV-induced invasive cancers and non HPV-induced gynaecological and anogenital cancers, said method comprising detection of hypermethylation in the ZIC1 and/or GHSR gene in a cell whereby such hypermethylation indicates the presence of HPV-induced precursor lesions with invasive potential, HPV-induced invasive cancers and non HPV-induced gynaecological and anogenital cancers. The invention further comprises the use of the ZIC1 and/or GHSR gene in such a method and a testkit for the detection of ZIC1 and/or GHSR methylation.