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1. (WO2017034315) COMPOSITION FOR PREVENTING OR TREATING MITOCHONDRIAL DISEASES CAUSED BY IMMUNOSUPPRESSANTS, AND IMMUNE DISEASES, CONTAINING METFORMIN
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Pub. No.: WO/2017/034315 International Application No.: PCT/KR2016/009376
Publication Date: 02.03.2017 International Filing Date: 24.08.2016
IPC:
A61K 31/155 (2006.01) ,A61K 31/436 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
13
Amines, e.g. amantadine
155
Amidines (), e.g. guanidine (H2N-C(NH)-NH2), isourea (HNC(OH)NH2), isothiourea (HNC(SH)-NH2)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
4353
ortho- or peri-condensed with heterocyclic ring systems
436
the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
Applicants:
가톨릭대학교 산학협력단 THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY- ACADEMIC COOPERATION FOUNDATION [KR/KR]; 서울특별시 서초구 반포대로 222, 가톨릭대학교 성의교정내 (반포동) (Banpo dong) Catholic University of Korea Songeui Campus, 222, Banpo-daero Seocho-gu, Seoul 06591, KR
Inventors:
조미라 CHO, Mi La; KR
양철우 YANG, Chul Woo; KR
박성환 PARK, Sung Hwan; KR
이선영 LEE, Seon Yeong; KR
박민정 PARK, Min Jung; KR
전주연 JHUN, Joo Yeon; KR
임선우 LIM, Sun Woo; KR
정병하 CHUNG, Byung Ha; KR
김은경 KIM, Eun Kyung; KR
김재경 KIM, Jae Kyung; KR
나현식 ΝΑ, Hyun-Sik; KR
김세영 KIM, Se-Young; KR
이은정 LEE, Eun Jung; KR
서현범 SEO, Hyeon-Beom; KR
Agent:
이희숙 LEE, Hee Sook; 서울시 강남구 테헤란로 33길 11, 9층 (역삼동, JS빌딩) 시원국제특허법률사무소 Siwon Intellectual Property Firm (JS Building, Yeoksam-dong) 9th Fl., 11, Teheran-ro 33 gil, Gangnam-gu, Seoul 06141, KR
Priority Data:
10-2015-011893424.08.2015KR
Title (EN) COMPOSITION FOR PREVENTING OR TREATING MITOCHONDRIAL DISEASES CAUSED BY IMMUNOSUPPRESSANTS, AND IMMUNE DISEASES, CONTAINING METFORMIN
(FR) COMPOSITION DESTINÉE À LA PRÉVENTION OU AU TRAITEMENT DES MALADIES MITOCHONDRIALES CAUSÉES PAR DES IMMUNOSUPPRESSEURS, ET DES MALADIES IMMUNITAIRES, CONTENANT DE LA METFORMINE
(KO) 면역억제제로 유발되는 미토콘드리아 질환 및 면역 질환의 예방 또는 치료를 위한 메트포민을 포함하는 조성물
Abstract:
(EN) The present invention relates to a composition for preventing or treating mitochondrial diseases caused by immunosuppressants, and immune diseases, containing metformin and, more specifically, to a composition for treating mitochondrial diseases caused by immunosuppressants, containing metformin; a pharmaceutical composition for preventing or treating immune diseases, containing, as active ingredients, metformin and an immunosuppressant, which is a target of rapamycin inhibitor (mTOR inhibitor); and a pharmaceutical composite formulation for preventing or treating immune diseases, containing, as ingredients, metformin and a mammalian target of rapamycin inhibitor, wherein the metformin and mammalian target of rapamycin inhibitor are administered simultaneously or separately, or administered in a predetermined sequence. The composition of the present invention effectively alleviates mitochondrial dysfunction, occurring as a side effect of conventional immunosuppressants, while having a more improved immunosuppressive therapeutic effect, thereby being usable in prevention and treatment of transplant rejection, autoimmune diseases, inflammatory diseases, and the like, all of which require immunosuppression.
(FR) La présente invention concerne une composition destinée à la prévention ou au traitement des maladies mitochondriales causées par des immunodépresseurs, et des maladies immunitaires, contenant de la metformine, et plus particulièrement une composition destinée au traitement des maladies mitochondriales causées par des immunodépresseurs, contenant de la metformine; une composition pharmaceutique destinée à la prévention ou au traitement des maladies immunitaires, contenant, comme principes actifs, de la metformine et un immunosuppresseur, qui est un inhibiteur de cible de rapamycine (inhibiteur de mTOR); et une formulation composite pharmaceutique destinée à la prévention ou au traitement des maladies immunitaires, contenant, comme principes, de la metformine et un inhibiteur de cible de rapamycine de mammifère, la metformine et l'inhibiteur de cible de rapamycine de mammifère étant administrés simultanément ou séparément, ou administrés dans une séquence prédéterminée. La composition de la présente invention atténue efficacement un dysfonctionnement mitochondrial, survenant sous forme d'effet secondaire d'immunosuppresseurs classiques, tout en ayant un effet thérapeutique immunosuppresseur amélioré, étant ainsi utilisable dans la prévention et le traitement d'un rejet de greffe, de maladies auto-immunes, de maladies inflammatoires et analogues, tous nécessitant une immunosuppression.
(KO) 본 발명은 면역억제제로 유발되는 미토콘드리아 질환 및 면역 질환의 예방 또는 치료를 위한 메트포민을 포함하는 조성물에 대한 것으로, 보다 상세하게는 면역억제제로 유발되는 미토콘드리아 질환 치료를 위한 메트포민을 포함하는 조성물, 메트포민과 라파마이신 표적 억제제 (mTOR inhibitor)인 면역억제제를 유효성분으로 포함하는 면역 질환의 예방 또는 치료용 약학적 조성물 및 메트포민과 포유류 라파 마이신 표적 억제제를 구성요소로 포함하며 이들을 동시에 또는 개별적으로 또는 정해진 순서로 투여하는 것을 특징으로 하는 면역 질환의 예방 또는 치료용 약학적 복합 제제에 관한 것이다. 본 발명의 조성물은 기존 면역억제제의 부작용으로 생기는 미토콘드리아의 기능 손상을 효과적으로 완화하고 면역억제 치료 효과는 더욱 향상되어, 면역억제가 필요한 이식거부반응, 자가면역 질환, 염증성 질환 등을 예방하거나 치료하는데 유용하게 이용될 수 있다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)