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1. (WO2017034301) PEPTIDE HAVING THE ACTIVITY OF EPITHELIAL GROWTH FACTOR, AND USE THEREFOR

Pub. No.:    WO/2017/034301    International Application No.:    PCT/KR2016/009325
Publication Date: Fri Mar 03 00:59:59 CET 2017 International Filing Date: Wed Aug 24 01:59:59 CEST 2016
IPC: C07K 7/06
C07K 14/485
A61K 8/64
A61Q 19/00
Applicants: PNP BIOPHARM CO., LTD.
주식회사 피앤피바이오팜
Inventors: SHIN, Hang Cheol
신항철
PARK, Yean Hee
박연희
OH, Jong Kwang
오종광
KIM, Dong Hwan
김동환
SIM, Min Sub
심민섭
Title: PEPTIDE HAVING THE ACTIVITY OF EPITHELIAL GROWTH FACTOR, AND USE THEREFOR
Abstract:
The present invention relates to a peptide and to a use therefor, the peptide exhibiting the growth activity of epithelial cells (keratinocytes) and fibroblasts comprised in the skin, and comprising an amino acid sequence represented by the following general formula: X1-Leu-X2-Glu-X3-Glu-X4, where X1 is Met, Ile, Phe, His, Lys, Arg, Glu or Ile, X2 is Lys, Arg, His or Asn, X3 is Trp, Gly His, Tyr or Arg, and X4 is Leu, Asp, Asn or Phe. The skin-cell growth peptide of the present invention is advantageous in that, as compared with natural EGF, said peptide has a lower molecular weight characteristic and thus highly outstanding skin permeability while at the same time having the same skin-cell growth ability. Consequently, a composition containing the peptide of the present invention is outstandingly efficacious in treating, preventing or alleviating a disease or condition in which EGF activity is required, and thus can be used in drugs, quasi-drugs, cosmetics and the like.