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1. (WO2017034173) BIOMARKER COMPOSITION FOR DIAGNOSING CANCER METASTASIS, CONTAINING AWP1
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2017/034173 International Application No.: PCT/KR2016/008612
Publication Date: 02.03.2017 International Filing Date: 04.08.2016
IPC:
G01N 33/574 (2006.01) ,G01N 33/50 (2006.01) ,C12Q 1/68 (2006.01) ,A61K 48/00 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
574
for cancer
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Applicants:
울산대학교 산학협력단 UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION [KR/KR]; 울산시 남구 대학로 93 93 Daehak-ro Nam-gu Ulsan 44610, KR
Inventors:
장은주 CHANG, Eun-Ju; KR
이은진 LEE, Eun-Jin; KR
Agent:
특허법인 태백 TAEBAEK INTELLECTUAL PROPERTY LAW FIRM; 서울시 금천구 가산디지털1로151 이노플렉스1차 601호 #601 Innoplex 1 cha, 151Gasandigital 1-ro Geumcheon-gu Seoul 08506, KR
Priority Data:
10-2015-012087827.08.2015KR
Title (EN) BIOMARKER COMPOSITION FOR DIAGNOSING CANCER METASTASIS, CONTAINING AWP1
(FR) COMPOSITION DE BIOMARQUEUR PERMETTANT DE DIAGNOSTIQUER DES MÉTASTASES CANCÉREUSES CONTENANT AWP1
(KO) AWP1을 포함하는 암 전이 진단용 바이오마커 조성물
Abstract:
(EN) The present invention relates to a biomarker composition for diagnosing cancer metastasis, containing AWP1, the composition being usable as a clinical indicator for cancer metastasis by identifying a decrease in the expression of AWP1 in cancers that easily metastasize in comparison to cancers that have not metastasized. In addition, it is ascertained that cancer growth and metastasis are increased when the expression of AWP1, having used siRNA, is inhibited and that, when AWP1 is overexpressed, cancer metastasis is inhibited by reducing cancer growth and migration, and thus AWP1 can be used as a cancer metastasis inhibitor.
(FR) L'invention concerne un composition de biomarqueur permettant de diagnostiquer des métastases cancéreuses contenant AWP1, la composition étant utilisable comme indicateur clinique de métastases cancéreuses par identification d'une diminution de l'expression de AWP1 dans des cancers facilement métastasés par comparaison à des cancers non métastasés. En outre, il est établi que la croissance tumorale et les métastases augmentent lorsque l'expression de AWP1, avec utilisation d'un ARNsi, est inhibée et que, lorsque AWP1 est surexprimé, la métastase cancéreuse est inhibée par réduction de la croissance cancéreuse et de la migration.
(KO) 본 발명은 AWP1을 포함하는 암 전이 진단용 바이오마커 조성물에 관한 것으로서, 전이되지 않은 암에 비해 전이가 잘 되는 암에서 AWP1의 발현이 감소함을 확인하여 암 전이에 대한 임상지표자로서 사용될 수 있다. 또한, siRNA를 사용한 AWP1 발현 억제시 암 생장과 전이가 증가함을 확인하였고, AWP1을 과발현시켰을 때 암 생장과 이동을 감소시켜 암 전이를 억제함을 확인하였기에 AWP1은 암 전이 억제제로 활용될 가능성이 있다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)