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1. (WO2017034024) LIGAND IMMOBILIZATION METHOD

Pub. No.:    WO/2017/034024    International Application No.:    PCT/JP2016/075000
Publication Date: Fri Mar 03 00:59:59 CET 2017 International Filing Date: Sat Aug 27 01:59:59 CEST 2016
IPC: G01N 30/88
B01D 15/08
B01J 20/281
C07K 1/22
C07K 16/00
Applicants: KANEKA CORPORATION
株式会社カネカ
Inventors: KONOIKE, Fuminori
鴻池 史憲
HONDA, Tatsuya
本田 達也
KARASUGI, Keiichi
唐杉 慶一
Title: LIGAND IMMOBILIZATION METHOD
Abstract:
The purpose of the present invention is to provide a method for strongly immobilizing a ligand on an insoluble formyl group–containing base material, wherein the method enables the production of an adsorbent, or the like, that significantly suppresses leakage of the ligand. This method for immobilizing, on an insoluble formyl group–containing base material, a ligand having an amino group and a specific affinity for a target compound is characterized by including a step for forming an imine by mixing the ligand and the insoluble formyl group–containing base material, and a step for reducing the imine using a borane complex having, as a ligand, a Lewis base with a pKa of 6.5 or lower.