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1. (WO2017033965) METHOD FOR PRODUCING AROMATIC COMPOUND AND DERIVATIVE THEREOF

Pub. No.:    WO/2017/033965    International Application No.:    PCT/JP2016/074649
Publication Date: Fri Mar 03 00:59:59 CET 2017 International Filing Date: Thu Aug 25 01:59:59 CEST 2016
IPC: C12P 7/22
C12N 1/15
C12N 1/19
C12N 1/21
C12P 7/40
C12P 7/42
C12P 13/22
C12N 15/09
Applicants: RIKEN
国立研究開発法人理化学研究所
Inventors: NODA Shuhei
野田 修平
SHIRAI Tomokazu
白井 智量
Title: METHOD FOR PRODUCING AROMATIC COMPOUND AND DERIVATIVE THEREOF
Abstract:
Provided is a method for producing an aromatic compound, e.g., salicylic acid, and a derivative thereof with high productivity using a microorganism. Provided are: a method for producing a microorganism having a modified sugar metabolic pathway, said method comprising introducing, into a microorganism, one or multiple genes each encoding an enzyme which can inhibit the expression of a phosphotransferase-type enzyme-encoding gene in the microorganism, can inhibit the expression of a pyruvate kinase-encoding gene in the microorganism, and enables the microorganism to synthesize the aromatic compound from chorismic acid or isochorismic acid; a genetically modified microorganism produced by the method; and a method for producing an aromatic compound and a derivative thereof, said method comprising culturing the microorganism and then collecting the aromatic compound and the like from the liquid culture.