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1. (WO2017033863) OSTEOBLASTS AND METHOD FOR PREPARING SAME

Pub. No.:    WO/2017/033863    International Application No.:    PCT/JP2016/074248
Publication Date: Fri Mar 03 00:59:59 CET 2017 International Filing Date: Sat Aug 20 01:59:59 CEST 2016
IPC: C12N 5/10
C12N 5/077
C12N 15/09
Applicants: KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION
京都府公立大学法人
Inventors: YAMAMOTO, Kenta
山本 健太
KISHIDA, Tsunao
岸田 綱郎
YAMAMOTO, Toshiro
山本 俊郎
MAZDA, Osam
松田 修
Title: OSTEOBLASTS AND METHOD FOR PREPARING SAME
Abstract:
The purpose of the present invention is to provide a method for preparing osteoblasts that have a low risk of undergoing malignant transformation, and that can be applied to repairing osseous defects associated with various tumors, injuries, and surgeries, etc., and for treating osteoporosis, bone fractures, and bone resorption represented by periodontal diseases. Provided as a means for solving such a problem is a method for preparing osteoblasts from somatic cells of a mammal, the method comprising a step for introducing Oct9 gene or an expression product thereof into the somatic cells.