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1. (WO2017033846) IMMUNOLOGICAL TEST METHOD AND IMMUNOLOGICAL TEST KIT

Pub. No.:    WO/2017/033846    International Application No.:    PCT/JP2016/074181
Publication Date: Fri Mar 03 00:59:59 CET 2017 International Filing Date: Sat Aug 20 01:59:59 CEST 2016
IPC: G01N 33/53
G01N 33/531
C07K 14/435
C07K 16/18
Applicants: FUSO PHARMACEUTICAL INDUSTRIES, LTD.
扶桑薬品工業株式会社
CANON KABUSHIKI KAISHA
キヤノン株式会社
Inventors: ASAKURA, Masahiro
朝倉 昌博
KESHI, Aya
芥子 亜矢
KOBAYASHI, Masaaki
小林 正昭
Title: IMMUNOLOGICAL TEST METHOD AND IMMUNOLOGICAL TEST KIT
Abstract:
In the present invention, it was found that, when measuring HMGB1 in a sample, using an antibody that binds to both HMGB2 and HMGB1, the reaction between HMGB2 and the HMGB1 antibody can be suppressed by also including an HMGB2 absorber (an HMGB2 antibody and/or an HMGB2 derived peptide that inhibits the binding of HMGB2 and the HMGB1 antibody). In other words, it was revealed that the HMGB1 in the sample alone can be measured or detected by contacting the HMGB1 antibody and the sample in the presence of the HMGB2 absorber.