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1. (WO2017033134) ENZYMATIC PROCESS FOR THE FOR PREPARATION OF (R)-1-(1-NAPHTHYL) ETHYLAMINE, AN INTERMEDIATE OF CINACALCET HYDROCHLORIDE

Pub. No.:    WO/2017/033134    International Application No.:    PCT/IB2016/055047
Publication Date: Fri Mar 03 00:59:59 CET 2017 International Filing Date: Thu Aug 25 01:59:59 CEST 2016
IPC: C12P 41/00
C12P 13/00
Applicants: LUPIN LIMITED
Inventors: CHILLARA, Sureshbabu
KHATIK, Amol, Gulab
HUSAIN, Mofazzal
Title: ENZYMATIC PROCESS FOR THE FOR PREPARATION OF (R)-1-(1-NAPHTHYL) ETHYLAMINE, AN INTERMEDIATE OF CINACALCET HYDROCHLORIDE
Abstract:
The present invention provides a process for the preparation of enantiomerically pure (R)- 1-(1-naphthyl)ethylamine of formula (IIa) by treating 1-acetylnaphthalene of formula (I) with R-selective transaminase enzyme in presence of amino donor. The (R)-1-(1-naphthyl)ethylamine of formula (IIa) thus obtained is further converted to cinacalcet hydrochloride of formula (III).