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1. (WO2017033128) BIPHENYL-SUBSTITUED 4-AMINO-BUTYRIC ACID DERIVATIVES AND THEIR USE IN THE SYNTHESIS OF NEP INHIBITORS

Pub. No.:    WO/2017/033128    International Application No.:    PCT/IB2016/055027
Publication Date: Fri Mar 03 00:59:59 CET 2017 International Filing Date: Wed Aug 24 01:59:59 CEST 2016
IPC: A61K 31/215
C07C 219/06
C07C 327/22
C07C 237/06
C07C 53/42
Applicants: NOVARTIS AG
HOOK, David
KU, Jie
ZHOU, Jianguang
Inventors: HOOK, David
KU, Jie
ZHOU, Jianguang
Title: BIPHENYL-SUBSTITUED 4-AMINO-BUTYRIC ACID DERIVATIVES AND THEIR USE IN THE SYNTHESIS OF NEP INHIBITORS
Abstract:
The invention relates to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, in particular neutral endopeptidase (NEP) inhibitors and prodrugs thereof.