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1. (WO2017033113) THERAPEUTIC COMBINATIONS OF A MEK INHIBITOR AND A BTK INHIBITOR

Pub. No.:    WO/2017/033113    International Application No.:    PCT/IB2016/054988
Publication Date: Fri Mar 03 00:59:59 CET 2017 International Filing Date: Sat Aug 20 01:59:59 CEST 2016
IPC: A61K 45/06
A61K 31/4184
A61K 31/454
A61K 31/4985
A61K 31/519
A61P 35/00
A61P 35/02
Applicants: ACERTA PHARMA B.V.
Inventors: ROTHBAUM, Wayne
LANNUTTI, Brian
KAPTEIN, Allard
Title: THERAPEUTIC COMBINATIONS OF A MEK INHIBITOR AND A BTK INHIBITOR
Abstract:
Therapeutic combinations of a MEK inhibitor and a Bruton's tyrosine kinase (BTK) inhibitor are described. In some embodiments, the invention provides pharmaceutical compositions comprising combinations of a MEK inhibitor and a BTK inhibitor and methods of using the pharmaceutical compositions for treating a disease, in particular a cancer.