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1. (WO2017032909) MUTANT STRAINS OF STAPHYLOCOCCUS AUREUS WITH MULTIPLE INACTIVATED TCS SYSTEMS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2017/032909 International Application No.: PCT/ES2015/070636
Publication Date: 02.03.2017 International Filing Date: 26.08.2015
IPC:
C12N 1/36 (2006.01) ,A61K 39/085 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1
Micro-organisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving micro-organisms or compositions thereof; Processes of preparing or isolating a composition containing a micro-organism; Culture media therefor
36
Adaptation or attenuation of cells
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
02
Bacterial antigens
085
Staphylococcus
Applicants:
UNIVERSIDAD PÚBLICA DE NAVARRA [ES/ES]; Campus de Arrosadia s/n (OTRI) Edificio del Rectorado E-31006 Pamplona, ES
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC) [ES/ES]; C/ Serrano, 117 E-28006 Madrid, ES
Inventors:
VILLANUEVA SAN MARTÍN, Maite; ES
GARCÍA MARTÍNEZ, Begoña; ES
VALLE TURRILLAS, Jaione; ES
PENADÉS CASANOVA, José R.; ES
MARTÍ JIMÉNEZ, Miguel; ES
TOLEDO ARANA, Alejandro; EE
LASA UZCUDUN, Iñigo; ES
Agent:
DE ELZABURU MÁRQUEZ, Alberto; ES
Priority Data:
Title (EN) MUTANT STRAINS OF STAPHYLOCOCCUS AUREUS WITH MULTIPLE INACTIVATED TCS SYSTEMS
(FR) SOUCHES MUTANTES DE STAPHYLOCOCCUS AUREUS AVEC SYSTÈMES TCS INACTIVÉS MULTIPLES
(ES) NUEVAS CEPAS DE STAPHYLOCOCCUS AUREUS Y SUS USOS
Abstract:
(EN) Disclosed are mutant strains of Staphylococcus aureus with multiple inactivated TCS systems. The invention relates to mutant strains of S. aureus deprived of all non-essential two-component signal systems (TCSs) and even the essential WalKR system, to intermediate mutants deprived of a number of TCSs, and to the uses thereof as a research and biotechnology platform. The mutants deprived of all non-essential TCSs are viable, stable in laboratory growth conditions, genetically modifiable, and capable of expressing heterologous proteins. The mutants enable individual analysis of each TCS, the use thereof as a target, and individual complementation of same, and allow information concerning perception systems that can be used for biotechnology applications based on or directed to S. aureus, such as identifying new antimicrobials, to be obtained.
(FR) L'invention concerne de nouvelles souches de Staphylococcus aureus et leurs utilisations. Elle concerne notamment des souches mutantes de S. aureus dépourvues de tous les systèmes de signalisation à deux composants (TCS) non essentiels, y compris le système essentiel walKR, les mutants intermédiaires dépourvus d’une pluralité de TCS et leurs utilisations comme plateforme d’investigation et biotechnologique. Les mutants dépourvus de tous les TCS non essentiels sont viables, stables dans des conditions de croissance de laboratoire, génétiquement modifiables et capables d’exprimer des protéines hétérologues. Ces mutants permettent l’analyse individuelle et l'utilisation comme cible de chaque TCS, leur complémentation individuelle, et l'obtention d’informations sur les systèmes de perception pouvant être utiles pour des applications biotechnologiques basées ou dirigées sur S. aureus, telles que l'identification de nouveaux agents antimicrobiens.
(ES) Nuevas cepas de Staphylococcus aureus y sus usos. La invención proporciona cepas mutantes de S. aureus desprovistas de todos los sistemas de señales de dos componentes (TCSs) no esenciales e incluso del sistema esencial wal KR, los mutantes intermedios desprovistos de un número de TCSs y sus usos como plataforma de investigación y biotecnológica. Los mutantes desprovistos de todos los TCSs no esenciales son viables, estables en condiciones de crecimiento de laboratorio, genéticamente modificables y capaces de expresar proteínas heterólogas. Tenerlos permite el análisis individual y la utilización como diana de cada TCS, su complementación individual y obtener información sobre los sistemas de percepción que pueden ser útiles para aplicaciones biotecnológicas basadas en o dirigidas a S. aureus, tales como la identificación de nuevos antimicrobianos.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Spanish (ES)
Filing Language: Spanish (ES)