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1. (WO2017032908) PHARMACEUTICAL COMPOSITION COMPRISING AMORPHOUS POSACONAZOLE
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Pub. No.: WO/2017/032908 International Application No.: PCT/EP2016/078902
Publication Date: 02.03.2017 International Filing Date: 25.11.2016
IPC:
A61K 9/14 (2006.01) ,A61K 31/496 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
14
Particulate form, e.g. powders
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
496
Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
Applicants:
SYNTHON B.V. [NL/NL]; Microweg 22 6545 CM Nijmegen, NL
Inventors:
GAGO GUILLAN, Manuel; ES
NOGUEIRAS NIETO, Luis; ES
ALVAREZ FERNANDEZ, Lisardo; ES
VELADA CALZADA, Jose; NL
Priority Data:
16178730.408.07.2016EP
Title (EN) PHARMACEUTICAL COMPOSITION COMPRISING AMORPHOUS POSACONAZOLE
(FR) COMPOSITION PHARMACEUTIQUE COMPRENANT DU POSACONAZOLE AMORPHE
Abstract:
(EN) The present invention relates to a pharmaceutical composition comprising a solid dispersion of posaconazole and at least two different enteric polymers, wherein the solid dispersion is obtained by applying the process of wet granulation. The invention further relates to the use of said pharmaceutical composition as medicament in the treatment of invasive fungal infections.
(FR) La présente invention concerne une composition pharmaceutique comprenant une dispersion une dispersion de posaconazole et au moins deux polymères entériques différents, ladite dispersion solide étant obtenue par application du processus de granulation par voie humide. L'invention concerne en outre l'utilisation de ladite composition en tant que médicament, notamment dans le traitement d'infections fongiques invasives.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)