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1. (WO2017032840) NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS

Pub. No.:    WO/2017/032840    International Application No.:    PCT/EP2016/070097
Publication Date: Fri Mar 03 00:59:59 CET 2017 International Filing Date: Fri Aug 26 01:59:59 CEST 2016
IPC: C07D 471/04
A61K 31/519
A61K 31/53
Applicants: JANSSEN PHARMACEUTICA NV
Inventors: WU, Tongfei
BREHMER, Dirk
BEKE, Lijs
BOECKX, An
DIELS, Gaston, Stanislas, Marcella
GILISSEN, Ronaldus, Arnodus, Hendrika, Joseph
LAWSON, Edward, Charles
PANDE, Vineet
PARADE, Marcus, Cornelis, Bernardus, Catharina
SCHEPENS, Wim, Bert, Griet
THURING, Johannes, Wilhelmus, John, F
VIELLEVOYE, Marcel
SUN, Weimei
MEERPOEL, Lieven
Title: NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS
Abstract:
The present invention relates novel 6-6 bicyclic aromatic ring substituted nucleoside analogues of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.