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1. (WO2017032837) METHOD FOR PREPARING A THREE-DIMENSIONAL POLYMER SCAFFOLD FOR TISSUE ENGINEERING

Pub. No.:    WO/2017/032837    International Application No.:    PCT/EP2016/070086
Publication Date: Fri Mar 03 00:59:59 CET 2017 International Filing Date: Fri Aug 26 01:59:59 CEST 2016
IPC: A61L 27/24
A61L 27/34
A61L 27/56
Applicants: BAER, Hans U.
Inventors: BAER, Hans U.
Title: METHOD FOR PREPARING A THREE-DIMENSIONAL POLYMER SCAFFOLD FOR TISSUE ENGINEERING
Abstract:
The present invention relates to a method for preparing a three-dimensional polymer scaffold (3D-PS) for use in tissue-engineering, said method comprising the subsequent steps of a) providing a polymeric precursor scaffold (p-PS) comprising at least one biodegradable natural polymer (PA); b) treating the polymeric precursor scaffold (p-PS) with a cross-linking agent comprising glutaraldehyde to induce cross-linking of the natural polymer (PA), thereby forming a cross-linked polymer scaffold (x-PS); c) subjecting the cross-linked polymer scaffold (x-PS) of step b) to low-pressure plasma treatment involving exposure of the polymer scaffold to an ionized oxygen-containing gas plasma at a pressure in the range of 10-3 to 10-6 bar and a temperature below 40°C.