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1. WO2017032798 - NOVEL INSULIN DERIVATIVES AND THE MEDICAL USES HEREOF

Publication Number WO/2017/032798
Publication Date 02.03.2017
International Application No. PCT/EP2016/069972
International Filing Date 24.08.2016
IPC
C07K 14/62 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
575Hormones
62Insulins
A61K 38/28 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
22Hormones
28Insulins
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 47/22
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
22Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
A61P 3/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
A61P 3/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
A61P 5/50
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
5Drugs for disorders of the endocrine system
48of the pancreatic hormones
50for increasing or potentiating the activity of insulin
Applicants
  • NOVO NORDISK A/S [DK]/[DK]
Inventors
  • MADSEN, Peter
  • MURRAY, Anthony
  • MÜNZEL, Martin
  • HJØRRINGGAARD, Claudia Ulrich
  • HOSTRUP, Susanne
  • GLENDORF, Tine
  • NORRMAN, Mathias
  • FLEDELIUS, Christian
Priority Data
15182282.225.08.2015EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NOVEL INSULIN DERIVATIVES AND THE MEDICAL USES HEREOF
(FR) NOUVEAUX DÉRIVÉS D'INSULINE ET LEURS UTILISATIONS MÉDICALES
Abstract
(EN)
The present invention is in the therapeutic fields of drugs for medical conditions relating to diabetes. More specifically the invention relates to novel acylated derivatives of human insulin analogues. The invention also provides pharmaceutical compositions comprising such insulin derivatives, and relates to the use of such derivatives for the treatment or prevention of medical conditions relating to diabetes.
(FR)
L'invention se rapporte aux domaines thérapeutiques des médicaments destinés à traiter des états pathologiques associés au diabète. Plus spécifiquement, l'invention concerne de nouveaux dérivés acylés d'analogues d'insuline humaine. Des compositions pharmaceutiques comprenant lesdits dérivés d'insuline, et l'utilisation de ces dérivés dans le traitement ou la prévention d'états pathologiques associés au diabète sont en outre décrites.
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