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1. (WO2017032777) CHIMERIC ANTIGEN RECEPTORS WITH INTEGRATED CONTROLLABLE FUNCTIONS

Pub. No.:    WO/2017/032777    International Application No.:    PCT/EP2016/069918
Publication Date: Fri Mar 03 00:59:59 CET 2017 International Filing Date: Thu Aug 25 01:59:59 CEST 2016
IPC: C07K 16/28
A61K 31/436
A61K 35/17
C07K 14/725
Applicants: CELLECTIS
Inventors: JUILLERAT, Alexandre
DUCHATEAU, Philippe
POIROT, Laurent
Title: CHIMERIC ANTIGEN RECEPTORS WITH INTEGRATED CONTROLLABLE FUNCTIONS
Abstract:
The present invention relates to the field of cell immunotherapy and more particularly to a new generation of chimeric antigen receptors (CAR), allowing the control of immune cells endowed with such CARs through the interaction with small molecules. More particularly, the present invention relates to chimeric antigen receptor which comprise in at least one ectodomain a molecular switch turning the antigen binding function of the receptor from an off to on state, and vice versa. The present invention thus provides more controlled and potentially safer engineered CAR endowed immune cells, such as T- lymphocytes.