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1. (WO2017032651) SALTS OF ACTIVE INGREDIENTS WITH POLYMERIC COUNTERIONS

Pub. No.:    WO/2017/032651    International Application No.:    PCT/EP2016/069457
Publication Date: Fri Mar 03 00:59:59 CET 2017 International Filing Date: Thu Aug 18 01:59:59 CEST 2016
IPC: A61K 9/16
A61K 31/00
C08F 220/06
Applicants: BASF SE
Inventors: SCHIFFTER, Heiko Alexander
ANGEL, Maximilian
KOLTER, Karl
GUTH, Felicitas
Title: SALTS OF ACTIVE INGREDIENTS WITH POLYMERIC COUNTERIONS
Abstract:
The invention relates to water-soluble polymeric salts of poorly water-soluble medicaments, consisting of a cationogenic medicament which has in an uncharged form or as a hydrochloride a solubility of less than 0.1 % (m/m) in water, artificial intestinal juice or gastric juice, and consisting of an anionogenic water-soluble polymer which has a water solubility of at least 5 % (m/m) in the pH range of 1 to 13 and is obtained by a radically initiated polymerization of a monomer mixture consisting of i) 70 to 90 wt.% of n-vinylpyrrolidone and ii) 10 to 30 wt.% of acrylic acid, the sum of i) and ii) corresponding to 100 wt.%.