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1. (WO2017032612) STEM CELLS WITH ENHANCED CLONOGENIC, MIGRATORY AND HOMING CAPACITIES

Pub. No.:    WO/2017/032612    International Application No.:    PCT/EP2016/069165
Publication Date: Fri Mar 03 00:59:59 CET 2017 International Filing Date: Fri Aug 12 01:59:59 CEST 2016
IPC: C12N 5/0789
A61K 35/17
A61K 35/28
C12N 5/0783
Applicants: FUNDACION PUBLICA ANDALUZA PROGRESO Y SALUD
ANTHONY NOLAN
THE FRANCIS CRICK INSTITUTE LIMITED
UCL BUSINESS PLC
IMPERIAL INNOVATIONS LIMITED
BANC DE SANG I TEIXITS
Inventors: SAUDEMONT, Aurore
MADRIGAL, José Alejandro
ESCOBEDO-COUSIN, Michelle
JACKSON, Nicola
LUEVANO, Martha
LAZA-BRIVIESCA, Raquel
DERNIAME, Sophie
ARIZA MCNAUGHTON, Linda
BONNET, Dominique
BLUNDELL, Michael
THRASHER, Adrian
COOPER, Nichola
SORIA ESCOMS, Bernat
HMADCHA, Abdelkrim
QUEROL, Sergio
Title: STEM CELLS WITH ENHANCED CLONOGENIC, MIGRATORY AND HOMING CAPACITIES
Abstract:
The invention relates to stem cells with enhanced clonogenic, migratory and homing capacities and a method of obtaining said stem cells comprising co-culturing said stem cells in contact with at least a resting or activated NK cell. Also relates to compounds and compositions comprising said stem cells and their use for the treatment of diseases that may benefit from tissue regeneration, bone marrow transplantation and wound healing.