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1. (WO2017032487) PROTEASOME INHIBITOR COMPRISING A SIGNAL-EMITTING MOIETY

Pub. No.:    WO/2017/032487    International Application No.:    PCT/EP2016/064957
Publication Date: Fri Mar 03 00:59:59 CET 2017 International Filing Date: Wed Jun 29 01:59:59 CEST 2016
IPC: C07K 5/087
C07K 5/062
C07K 5/103
C07K 5/107
C07K 5/083
A61K 38/00
Applicants: TECHNISCHE UNIVERSITÄT MÜNCHEN
Inventors: DUBIELLA, Christian
GROLL, Michael
Title: PROTEASOME INHIBITOR COMPRISING A SIGNAL-EMITTING MOIETY
Abstract:
The present invention relates to compounds such as peptides which act as proteasome inhibitors. The compounds are covalently linked with a signal emitting compound or a precursor thereof, via an ester such as a sulfonic ester group for imaging of the inhibition of the proteasome. The compound is for use in the quantification of proteasomal inhibition, diagnosis and/or prevention and/or treatment of autoimmune diseases, cancer, neurodegenerative diseases, viral infections and/or diseases associated with inflammation. The invention further relates to methods to produce the compounds.